IN-LINE PRODUCT QUALITY MONITORING DURING BIOPHARMACEUTICAL MANUFACTURING USING COMPUTATIONAL RAMAN SPECTROSCOPY

ABSTRACTThe implementation of process analytical technologies is positioned to play a critical role in advancing biopharmaceutical manufacturing by simultaneously resolving clinical, regulatory, and cost challenges.Raman spectroscopy is emerging as a key technology enabling Urn Element in-line product quality monitoring, but laborious calibration a

IntroductionFor reference genomes and gene annotations are key materials that can determine the limits of the molecular biology research of a species; however, systematic research on their quality assessment remains insufficient.MethodsWe collected reference assemblies, gene annotations, and 3,420 RNA-sequencing (RNA-seq) data from 114 species and